Alzheimer's disease and Down's syndrome antibodies bind to the heavy neurofilament protein of cholinergic neurons.

induce memory dysfunction in rats. Neuroscience, 40, cerebrovascular amyloid in Alzheimer’s disease (AD). 297-305. Sot. Neurosci. Abs., 17, 912. Forster, M.J. & Lal, H. (1991), Autoimmunity and cognitive decline in aging and Alzheimer’s disease, in “Psychoneuroimmunology, Second Edition” (R. Ader, N. Cohen & D. Felten) (pp. 709-748). Academic Press, New York, London. Gaskin, F. (1992), Human antibodies to Alzheimer’s disease and normal neural elements, in “Alzheimer’s disease, new treatment strategies” (Q.S. Khachaturian and J.P. Blass) (pp. 137-145). Marcel Dekker Inc., New York. Gaskin, F., Farlow, M.R. & Fu, SM. (1989), Human antibodies preferentially reactive with brain or with temporal cortex in Alzheimer’s disease. Sot. Neurosci. Abs., 15, 330. Gaskin, F. & Finley, J. (1991), Human antibodies reactive with amyloid beta protein in neuritic plaques and Gaskin, F., Kingsley, B.S. & Fu, S.M. (1987), Autoantibodies to neurofibrillary tangles and brain tissue in Alzheimer’s disease. J. exp. Med., 165, 245250. Kingsley, B.S., Gaskin, F. & Fu, S.M. (1988), Human antibodies to neurofibrillary tangles and astrocytes in Alzheimer’s disease. J. Neuroimmunol., 19, 89-99. Levine, B., Hardwick, J.M., Trapp, B.D., Crawford, T.O., Bollinger, R.C. & Griffin, D.E. (1991), Antibody-mediated clearance of alphavirus infection from neurons. Science, 254, 856-860. Selkoe, D.J. (1991), The molecular pathology of Alzheimer’s disease. Neuron, 6, 487-498. Simpson, J., Boyd, J.E., Yates, C.M., Christie, J.E., Fink, G., James, K. & Gordon, A. (1986), Autoantibodies to Alzheimer and normal brain structures from virustransformed lymphocytes. J. Neuroimmunol., 13, l-8.